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万古霉素致DRESS综合征22例文献分析
Analysis of 22 cases of drug rash with eosinophilia and systemic symptoms syndrome by vancomycin based on literature review
目的：分析万古霉素致伴嗜酸性粒细胞增多和系统症状的药疹综合征（DRESS综合征）的发生规律及特点，为安全用药提供参考。方法：检索国内外库收载的万古霉素致DRESS综合征文献进行分析。结果：共筛选出有效个案报道15篇，22例患者，其中男14例，女8例，青少年2例。用药至发生DRESS综合征的平均时间为3周。临床表现主要为皮疹、发热、嗜酸性粒细胞增多并累及多器官损伤，最常见受累的器官为肝脏（16例，72.7%）。结论：临床医师应了解万古霉素致DRESS综合征的规律和特点，加强用药监测，以便及时发现和处理DRESS综合征。
OBJECTIVE To analyze the general patterns and characteristics of drug rash with eosinophilia and systemic symptoms syndrome (DRESS) induced by vancomycin and provide a reference for clinical medication. METHODS DRESS of vancomycin reported in domestic and foreign academic journals were collected and analyzed statistically. RESULTS A total of 15 reports involving 22 patients were collected, including 14 men and 8 women. Of 22 cases, there were 2 teenage patients. The average occurrence time of DRESS induced by vancomycin was 3 weeks (range:7 to 34 days). The main clinical manifestations were rash, fever, eosinophilia and multiple organ injury. The most common damaged organ was the liver (n=16, 72.7%). CONCLUSION Clinicians should be aware of rules and characteristics of DRESS induced by vancomycin and tighten monitoring on it to detect and deal with DRESS.
万古霉素 / 伴嗜酸性粒细胞增多和系统症状的药疹综合征 / 文献分析 {{custom_keyword}} /
vancomycin / drug rash with eosinophilia and systemic symptoms syndrome / literature analysis {{custom_keyword}} /
[1] Tao LN,Qu XY,Zhang SX, et al. Analysis of 720 Patients of Clinical Use of Vancomycin in Our Hospital from 2013 to 2014[J].China Pharmacy(中国药房),2017, 28(12):1647-1651.
[2] Marik PE,Ferris N.Delayed hypersensitivity reaction to vancomycin[J].Pharmacotherapy,1997,17(6):1341-1344.
[3] Li B,Gao R,Li R, et al. Causal determination of the adverse events and adverse drug reactions in drug clinical trials[J]. Chin J New Drugs(中国新药杂志),2014, 23(12):1465-1470.
[4] Yazganoglu KD,Ozkaya E,Ergin-Ozcan P,et al. Vancomycin-induced drug hypersensitivity syndrome[J]. J Eur Acad Dermatol Venereol, 2005,19(5):648-650.
[5] Zuliani E, Zwahlen H, Gilliet F, et al. Vancomycin-induced hypersensitivity reaction with acute renal failure:resolution following cyclosporine treatment[J].Clin Nephrol, 2005,64(2):155-158.
[6] Kwon HS,Chang YS,Jeong YY,et al. A case of hypersensitivity syndrome to both vancomycin and teicoplanin[J].J Korean Med Sci,2006,21(6):1108-1110.
[7] Tamagawa-Mineoka R, Katoh N, Nara T, et al. DRESS syndrome caused by teicoplanin and vancomycin, associated with reactivation of human herpesvirus-6[J].Int J Dermatol,2007,46(6):654-655.
[8] Vauthey L,Uçkay I,Abrassart S,et al. Vancomycin-induced DRESS syndrome in a female patient[J].Pharmacology,2008,82(2):138-141.
[9] Vinson AE,Dufort EM,Willis MD, et al. Drug rash, eosinophilia, and systemic symptoms syndrome:Two pediatric cases demonstrating the range of severity in presentation——A case of vancomycin-induced drug hypersensitivity mimicking toxic shock syndrome and a milder case induced by minocycline[J].Pediatr Crit Care Med,2010,11(4):e38-43.
[10] O'Meara P, Borici-Mazi R, Morton AR, et al. DRESS with delayed onset acute interstitial nephritis and profound refractory eosinophilia secondary to Vancomycin[J].Allergy Asthma Clin Immunol,2011,7:16.
[11] Blumenthal KG, Patil SU, Long AA. The importance of vancomycin in drug rash with eosinophilia and systemic symptoms (DRESS) syndrome[J].Allergy Asthma Proc,2012,33(2):165-171.
[12] Díaz-Mancebo R, Costero-Fernández O, Vega-Cabrera C, et al. Dress syndrome and acute tubulointerstitial nephritis after treatment with vancomycin and beta-lactams[J]. Nefrologia, 2012,32(5):685-687.
[13] Young S, Ojaimi S, Dunckley H, et al. Vancomycin associated drug reaction with eosinophilia and systemic symptoms syndrome[J]. Intern Med J, 2014,44(7):694-696.
[14] Güner MD,Tuncbilek S,Akan B,et al. Two cases with HSS/DRESS syndrome developing after prosthetic joint surgery:does vancomycin-laden bone cement play a role in this syndrome?[J].BMJ Case Rep,2015,2015.
[15] Kim KM, Sung K, Yang HK, et al. Acute tubular necrosis as a part of vancomycin induced drug rash with eosinophilia and systemic symptoms syndrome with coincident postinfectious glomerulonephritis[J]. Korean J Pediatrics,2016,59(3):145-148.
[16] Miyazu D,Kodama N,Yamashita D,et al. DRESS Syndrome Caused by Cross-reactivity Between Vancomycin and Subsequent Teicoplanin Administration:A Case Report[J]. Am J Case Rep,2016,17:625-631.
[17] Wilcox O,Hassanein M,Armstrong J, et al. Case report:atypical presentation of vancomycin induced DRESS syndrome:a case report and review of the literature[J]. BMC Pulm Med,2017,17(1):217.
[18] Husain Z,Reddy BY,Schwartz RA.DRESS syndrome:Part I.Clinical perspectives[J].J Am Acad Dermatol,2013,68(5):693.el-e14.
[19] Cacoub P, Musette P, Descamps V,et al.The DRESS syndrome:a literature review[J].Am J Med,2011,124(7):588-597
[20] Hiransuthikul A, Rattananupong T, Klaewsongkram J, et al. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS):11 years retrospective study in Thailand[J].Allergol Int,2016,65(4):432-438.
[21] Bocquet H,Bagot M,Roujeau JC.Drug-indueed pseudolymphoma and drug hypersensitivity syndrome(drug rash with eosinophilia and systemic symptoms:DRESS)[J].Semin Cumn Med Surg,1996,15(4):250-257.
[22] Kardaun SH, Sidoroff A, Valeyrie-Allanore L, et al. Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms:Does a DRESS syndrome really exist?[J]. Br J Dermatol, 2007,156:609-611.
[23] Shiohara T, Iijima M, Ikezawa Z,et al The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations[J].Br J Dermatol,2007,156(5):1083-1084.
[24] Funck-Brentano E, Duong TA, Bouvresse S, et al.Therapeutic management of DRESS:a retrospective study of 38 cases[J]. J Am Acad Dermatol,2015,72(2):246-252.
[25] Criado PR, Avancini J, Santi CG, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS):a complex interaction of drugs, viruses and the immune system[J]. Isr Med Assoc J,2012,14(9):577-582.
[26] Ushigome Y,Kano Y,Ishida T,et al. Short-and long-term outcomes of 34 patients with drug-induced hypersensitivity syndrome in a single institution[J]. J Am Acad Dermatol, 2013,68(5):721-728.
[27] McCormack M, Alfirevic A, Bourgeois S,et al.HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans[J].N Engl J Med, 2011,364(12):1134-1143.
[28] Mugwagwa AN, Fischer R, Zailan I. HLA-B*5801:a genetic susceptibility to allopurinol-induced DRESS[J]. Med J Aust, 2016,204(4):159-160.
[29] Criado PR,Avancini J,Santi CG,et al.Drug reaction with eosinophilia and systemic symptoms(DRESS):a complex interaction of drugs,viruses and the immune system[J].Isr Med Assoc J,2012,14(9):577-582.
[30] De A, Rajagopalan M, Sarda A,et al.Drug Reaction with Eosinophilia and Systemic Symptoms:An Update and Review of Recent Literature[J].Indian J Dermatol,2018,63(1):30-40.
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